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KMID : 0613320120180020066
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Journal of the Korean Bone and Joint Tumor Soceity
2012 Volume.18 No. 2 p.66 ~ p.71
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Oncologic Outcome of Sacral Chordoma
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Cho Sang-Hyun
Lee Soo-Yong
Jeon Dae-Geun
Song Won-Seok
Kong Chang-Bae
Lee Jeong-Dong
Cho Wan-Hyeong
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Abstract
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Purpose: We analyzed treatment result to examine the outcome for patients with sacral chordoma and to determine relevant prognostic factors.
Materials and Methods: We retrospectively reviewed 19 patients with sacral chordoma seen at out institution between 1990 and 2010. There were 9 men and 10 women with mean age of 56 years. The average follow up was 63 months (range, 25-144 months). 15 patient received surgical treatment, six of these patient had wide, eight had marginal, one had intralesional margin and 4 patient treated with Radiation therapy only.
Results: The disease free and overall survival rate for all 19 patients was 34.7% and 79.7% at 5-years, respectively. Statistical analysis using the log-rank test revealed no significant difference between the surgery and radiation therapy groups in overall survival (p=0.54). Nine of 19 patients had local recurrence at a median of 2.5 years postoperatively. Seven of these 9 patients had distant metastasis at a median of 4.5 years postoperatively. Among the variables, tumor size (p=0.033) and tumor involvement of above S3 (p=0.032) were independent prognostic factor for overall survival. Nine of 15 patients who received surgical treatment had postoperative complication such as voiding difficulty and incontinence.
Conclusion: Careful consideration of the patient general condition and predictable complication of the treatment might be the best way to improve patient’s survival and quality of life.
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KEYWORD
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sacrum, chordoma, prognostic factor
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